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    2. 8-羥基喹啉銅

      • 基本信息
      • 制備方法及用途
      • 物化性質
      • 安全信息
      • 毒理性
      • MSDS
      • 海關數據
      • 結構與計算化學
      • 上游產品
      • 表征圖譜

      8-羥基喹啉銅 基本信息

      中文名稱:
      8-羥基喹啉銅 
      中文別名:
      喹啉銅;
      8-羥基喹啉銅(II) 
      英文名稱:
      Copper quinolate
      英文別名:
      oxine-copper;
      Culinate;
      Copper quinolate;
      8-Hydroxyquinoline copper complex;
      Milmer;
      bis(8-quinolinolato-κN1,κO8)copper;
      copper(II) bis(quinolin-8-olate);
      Oxine-Copper;
      Cunilate;
      oxine-Cu;
      bis(8-hydroxyquinolinato)copper(II);
      Dokirin;
      Copper(II) Bis(8-hydroxyquinolinate);
      bioquin1;
      Milmer 1;
      8-Hydroxyquinoline Copper Salt;
      (8-hydroxy quinolinato)2Cu;
      Copper-8-quinolinolate;
      Copper-8;
      Fruitdo;
      [Cu(8-HQ)2];
      bis(quinolin-8-olato-O,N)copper(II);
      Dokivin;
      copper 8-quinolinolate;
      cupric 8-quinolinoxide;
      bis(8-hydroxyquinolato)copper(II);
      Bis(8-quinolinolato)copper(II);
      QUINONDO;
      Bis(8-hydroxyquinolinato)copper(II) 
      CAS No.:
      10380-28-6
      分 子 式:
      C18H12CuN2O2
      分 子 量:
      351.85
      精確分子量:
      351.01900
      PSA:
      44.24000
      EINECS:
      233-841-9
      InChI:
      InChI=1/2C10H7NO3.Cu/c2*12-8-3-1-2-6-4-5-7(10(13)14)11-9(6)8;/h2*1-5,12H,(H,13,14);/q;;+2/p-2
      危險品標志:
      IrritantXi
      風險術語:
      R36/37/38;
      安全術語:
      S26;S36;
      分子結構式:
      SDS:
      查看

      8-羥基喹啉銅 制備方法及用途

      制備方法

      本品為殺菌防霉劑,主要用于聚氨酯塑料橡膠、皮革、紙張、紡織、涂料、木材等等,也可用作農藥、醫藥、合成金屬緩蝕劑等方面。

      用途簡介

      用途

      用作殺菌劑,用于防治蘋果樹輪紋病等。

      8-羥基喹啉銅 物化性質

      外觀與性狀:
      黃色至綠色粉末
      密度:
      1,68 g/cm3
      熔點:
      240?°C (dec.)(lit.)
      沸點:
      267oC at 760 mmHg
      閃點:
      143.1oC
      存儲條件/存儲方法:
      庫房通風低溫干燥
      穩定性相關:

      遵照規格使用和儲存則不會分解。

       

      其它信息:

      1.       性狀:黃綠色結晶固體

      2.       密度(g/mL,25/4): 1.68

      3.       相對蒸汽密度(g/mL,空氣=1):無可用

      4.       熔點(ºC):240

      5.       沸點(ºC,常壓):無可用

      6.       沸點(ºC,5.2kPa): 無可用

      7.       折射率: 無可用

      8.       閃點(ºC): 無可用

      9.       比旋光度(º):無可用

      10.    自燃點或引燃溫度(ºC):無可用

      11.    蒸氣壓(kPa,25ºC):無可用

      12.    飽和蒸氣壓(kPa,60ºC):無可用

      13.    燃燒熱(KJ/mol):無可用

      14.    臨界溫度(ºC):無可用

      15.    臨界壓力(KPa):無可用

      16.    油水(辛醇/水)分配系數的對數值:無可用

      17.    爆炸上限(%,V/V):無可用

      18.    爆炸下限(%,V/V): 無可用

      19.    溶解性:不溶于水。

      8-羥基喹啉銅 安全信息

      海關代碼:
      2933499090
      WGK_Germany:
      3
      德國有關水污染物質的分類清單
      危險類別碼:
      R36/37/38
      安全說明:
      S26-S36
      RTECS號:
      VC5250000
      安全標志:
      S26:萬一接觸眼睛,立即使用大量清水沖洗并送醫診治。
      S36:穿戴合適的防護服裝。
      危險標志:
      Xi

      8-羥基喹啉銅 毒理性

      CHEMICAL IDENTIFICATION

      RTECS NUMBER :
      VC5250000
      CHEMICAL NAME :
      8-Quinolinol, copper (II) chelate
      CAS REGISTRY NUMBER :
      10380-28-6
      LAST UPDATED :
      199710
      DATA ITEMS CITED :
      20
      MOLECULAR FORMULA :
      C18-H12-Cu-N2-O2
      MOLECULAR WEIGHT :
      351.86
      WISWESSER LINE NOTATION :
      T66 BNJ JO 2-CU-

      HEALTH HAZARD DATA

      ACUTE TOXICITY DATA

      TYPE OF TEST :
      LD50 - Lethal dose, 50 percent kill
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Rodent - rat
      DOSE/DURATION :
      9930 mg/kg
      TOXIC EFFECTS :
      Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
      TYPE OF TEST :
      LC50 - Lethal concentration, 50 percent kill
      ROUTE OF EXPOSURE :
      Inhalation
      SPECIES OBSERVED :
      Rodent - rat
      DOSE/DURATION :
      820 mg/m3
      TOXIC EFFECTS :
      Details of toxic effects not reported other than lethal dose value
      TYPE OF TEST :
      LD50 - Lethal dose, 50 percent kill
      ROUTE OF EXPOSURE :
      Intraperitoneal
      SPECIES OBSERVED :
      Rodent - rat
      DOSE/DURATION :
      22 mg/kg
      TOXIC EFFECTS :
      Details of toxic effects not reported other than lethal dose value
      TYPE OF TEST :
      LD50 - Lethal dose, 50 percent kill
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Rodent - mouse
      DOSE/DURATION :
      3940 mg/kg
      TOXIC EFFECTS :
      Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
      TYPE OF TEST :
      LD50 - Lethal dose, 50 percent kill
      ROUTE OF EXPOSURE :
      Intraperitoneal
      SPECIES OBSERVED :
      Rodent - mouse
      DOSE/DURATION :
      67 mg/kg
      TOXIC EFFECTS :
      Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
      TYPE OF TEST :
      LD50 - Lethal dose, 50 percent kill
      ROUTE OF EXPOSURE :
      Administration onto the skin
      SPECIES OBSERVED :
      Rodent - rabbit
      DOSE/DURATION :
      >2 gm/kg
      TOXIC EFFECTS :
      Details of toxic effects not reported other than lethal dose value
      TYPE OF TEST :
      TDLo - Lowest published toxic dose
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Rodent - rat
      DOSE/DURATION :
      48 gm/kg/30D-I
      TOXIC EFFECTS :
      Liver - liver function tests impaired Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
      TYPE OF TEST :
      TDLo - Lowest published toxic dose
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Rodent - rat
      DOSE/DURATION :
      87600 mg/kg/2Y-C
      TOXIC EFFECTS :
      Liver - other changes Kidney, Ureter, Bladder - other changes Endocrine - changes in spleen weight
      TYPE OF TEST :
      TDLo - Lowest published toxic dose
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Rodent - mouse
      DOSE/DURATION :
      21840 mg/kg/13W-C
      TOXIC EFFECTS :
      Liver - other changes Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
      TYPE OF TEST :
      TDLo - Lowest published toxic dose
      ROUTE OF EXPOSURE :
      Oral
      SPECIES OBSERVED :
      Mammal - dog
      DOSE/DURATION :
      54600 mg/kg/2Y-C
      TOXIC EFFECTS :
      Gastrointestinal - malabsorption Liver - hepatitis (hepatocellular necrosis), diffuse Liver - change in gall bladder structure or function
      TYPE OF TEST :
      TDLo - Lowest published toxic dose
      ROUTE OF EXPOSURE :
      Subcutaneous
      SPECIES OBSERVED :
      Rodent - mouse
      DOSE/DURATION :
      156 mg/kg/39W-I
      TOXIC EFFECTS :
      Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

      MUTATION DATA

      TYPE OF TEST :
      Mutation in microorganisms
      TEST SYSTEM :
      Bacteria - Salmonella typhimurium
      DOSE/DURATION :
      5 ug/plate
      REFERENCE :
      MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,185,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,103,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,103,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82785 No. of Facilities: 28 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 792 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82785 No. of Facilities: 33 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 406 (estimated)
      毒理學數據:

      1 。
      試驗方法:
      攝入劑量: 5微克/板
      測試對象:細菌-鼠傷寒沙門氏菌
      毒性類型:突變
      毒性作用: 2 。
      試驗方法:口服
      攝入劑量: 48 mg/kg/30D-I
      測試對象:嚙齒動物-鼠
      毒性類型: MutipleDose
      毒性作用: 1.肝臟受損的肝功能試驗
      2.營養和總代謝-體重減輕或減少體重增加
      3.慢性數據-死亡

      3 。
      試驗方法:口服
      攝入劑量: 87600 mg/kg/2Y-C
      測試對象:嚙齒動物-鼠
      毒性類型: MutipleDose
      毒性作用: 1.肝臟發生變化
      2.腎 ,輸尿管,膀胱-其他變化
      3.導致脾臟重量變化

      4 。
      試驗方法:口服
      攝入劑量: 2.184萬mg/kg/13W-C
      測試對象:嚙齒動物-鼠
      毒性類型: MutipleDose
      毒性作用: 1.Liver -其他變化
      2.導致脾臟重量變化
      3.酶抑制,誘導或改變血液或組織水平-真正膽堿酯酶
      生態數據:

      該物質對環境可能有危害,對水體應給予特別注意。

      8-羥基喹啉銅 MSDS


      Section 1. Chemical Product and Company Identification
          8-Hydroxyquinoline, Copper Salt
          Common Name/
          Trade Name
          Manufacturer
          Commercial Name(s)
          Synonym
          Chemical Name
          Chemical Family
          8-Hydroxyquinoline, Copper Salt

      Section 4. First Aid Measures
          Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
          least 15 minutes. Get medical attention.
          Skin Contact        In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove    
          contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get
          medical attention.
          Serious Skin Contact        Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical    
          attention.
          Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
          medical attention.
          Serious Inhalation        Not available.    
          Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
          unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if
          symptoms appear.
          Serious Ingestion        Not available.    

      Section 5. Fire and Explosion Data
          Flammability of the Product May be combustible at high temperature.
          Auto-Ignition Temperature Not available.
          Flash Points        Not available.    
          Flammable Limits        Not available.    
          Products of Combustion        These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).    
          Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
          Various Substances
          Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
          of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
          Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
          and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
          Special Remarks on        Not available.    
          Fire Hazards
          Special Remarks on Explosion Not available.
          Hazards

      Section 6. Accidental Release Measures
          Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
          spreading water on the contaminated surface and dispose of according to local and regional authority
          requirements.
          Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water    
          on the contaminated surface and allow to evacuate through the sanitary system.
          8-Hydroxyquinoline, Copper Salt

      Section 7. Handling and Storage
          Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
          ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable
          respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid
          contact with skin and eyes.
          Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).    
          Refrigerate.

      Section 8. Exposure Controls/Personal Protection
          Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
          recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
          airborne contaminants below the exposure limit.
          Personal Protection        Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
          Gloves.
          Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
          a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
          BEFORE handling this product.
          Exposure Limits        Not available.    

      Section 9. Physical and Chemical Properties
          Physical state and appearance Solid. (crystalline powder)        Odor        Not available.    
          Not available.
          Taste
          Molecular Weight        351.85 g/mole    
          greenish-yellow
          Color
          Not applicable.
          pH (1% soln/water)
          Boiling Point        Not available.    
          Melting Point        >200°C (392°F)    
          Critical Temperature        Not available.    
          Specific Gravity        Not available.    
          Not applicable.
          Vapor Pressure
          Vapor Density        Not available.    
          Not available.
          Volatility
          Odor Threshold        Not available.    
          Water/Oil Dist. Coeff.        Not available.    
          Ionicity (in Water)        Not available.    
          Dispersion Properties        Not available.    
          Solubility        Insoluble in cold water, hot water.    

      Section 10. Stability and Reactivity Data
          Stability        The product is stable.    
          Instability Temperature        Not available.    
          Conditions of Instability        Excess heat, excess dust generation    
          Incompatibility with various        Not available.    
          substances
          Corrosivity        Not available.    
          8-Hydroxyquinoline, Copper Salt
          Special Remarks on        Not available.    
          Reactivity
          Special Remarks on        Not available.    
          Corrosivity
          Polymerization        Will not occur.    

      Section 11. Toxicological Information
          Routes of Entry        Inhalation. Ingestion.    
          Toxicity to Animals        Acute oral toxicity (LD50): 3940 mg/kg [Mouse].    
          Acute dermal toxicity (LD50): >2000 mg/kg [Rabbit].
          Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
          Other Toxic Effects on        Hazardous in case of inhalation.    
          Humans        Slightly hazardous in case of skin contact (irritant, permeator), of ingestion.    
          Special Remarks on        Lethal Dose/Conc 50% Kill:    
          Toxicity to Animals        LC50 [Rat] - Route: Inhalation; Dose: 820 mg/kg.    
          *Please Note that the time period for testing was not indicated by the Registery of Toxic Effects of Chemial
          Substances (RTECS).
          Special Remarks on        May affect genetic material and may cause cancer based on animal data. No human data found.    
          Chronic Effects on Humans
          Special Remarks on other        Acute Potential Health Effects:    
          Toxic Effects on Humans        Skin: May cause skin irritation. It may be absorbed through the skin.    
          Eye: Dust may cause eye irritation.
          Inhalation: Dust may cause respiratory tract irritation. May be harmful if inhaled.
          Ingestion: May affect behavior (somnolence - general depressed activity), gastrointestinal tract (irritation,
          diarrhea, hypermotility), repiratory system (dyspnea), nervous system
          Chronic Potential Health Effects: liver (hepatitis), urinary system, spleen, metabolism (weight loss), blood.

      Section 12. Ecological Information
          Ecotoxicity        Not available.    
          BOD5 and COD        Not available.    
          Possibly hazardous short term degradation products are not likely. However, long term degradation products may
          Products of Biodegradation
          arise.
          The products of degradation are less toxic than the product itself.
          Toxicity of the Products
          of Biodegradation
          Special Remarks on the        Not available.    
          Products of Biodegradation

      Section 13. Disposal Considerations
          Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
          control regulations.
          8-Hydroxyquinoline, Copper Salt

      Section 14. Transport Information
          DOT Classification        Not a DOT controlled material (United States).    
          Identification        Not applicable.    
          Not applicable.
          Special Provisions for
          Transport
          DOT (Pictograms)

      Section 15. Other Regulatory Information and Pictograms
          TSCA 8(b) inventory: 8-Hydroxyquinoline, Copper Salt
          Federal and State
          Regulations
          California        California prop. 65: This product contains the following ingredients for which the State of California has found    
          to cause cancer which would require a warning under the statute: No products were found.
          Proposition 65
          Warnings
          California prop. 65: This product contains the following ingredients for which the State of California has found
          to cause birth defects which would require a warning under the statute: No products were found.
          Other Regulations        EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.    
          233-841-9).
          Canada: Listed on Canadian Non-Domestic Substance List (NDSL).
          China: Listed on National Inventory.
          Japan: Listed on National Inventory (ENCS).
          Korea: Listed on National Inventory (KECI).
          Philippines: Listed on National Inventory (PICCS).
          Australia: Listed on AICS.
          WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
          Other Classifications
          DSCL (EEC)
          R20- Harmful by inhalation.        S22- Do not breathe dust.    
          Health Hazard
          HMIS (U.S.A.)        2 National Fire Protection    
          1 Flammability
          1 Association (U.S.A.)
          Fire Hazard
          2 0 Reactivity
          Health
          Reactivity
          0
          Specific hazard
          Personal Protection
          E
          WHMIS (Canada)
          (Pictograms)
          DSCL (Europe)
          (Pictograms)
          TDG (Canada)
          (Pictograms)
          8-Hydroxyquinoline, Copper Salt
          ADR (Europe)
          (Pictograms)
          Protective Equipment
          Gloves.
          Lab coat.
          Dust respirator. Be sure to use an
          approved/certified respirator or
          equivalent.


      SECTION 16 - ADDITIONAL INFORMATION
      N/A

      8-羥基喹啉銅 海關數據

      中國海關編碼:2933499090

      概述:
      2933499090. 其他含喹琳或異喹啉環系的化合物〔但未進一步稠合的〕. 增值稅率:17.0%. 退稅率:13.0%. 監管條件:無. 最惠國關稅:6.5%. 普通關稅:20.0%
      申報要素:
      品名, 成分含量, 用途, 烏洛托品請注明外觀, 6-己內酰胺請注明外觀, 簽約日期
      摘要/Summary:
      2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

      8-羥基喹啉銅 分子結構與計算化學數據

      分子結構數據

      1、摩爾折射率:無可用

      2、   摩爾體積(cm3/mol): 無可用

      3、   等張比容(90.2K):無可用

      4、   表面張力(dyne/cm):無可用

      計算化學數據

      1、   疏水參數計算參考值(XlogP):無可用

      2、   氫鍵供體數量:2

      3、   氫鍵受體數量:8

      4、   可旋轉化學鍵數量:0

      5、   拓撲分子極性表面積(TPSA):147

      6、   重原子數量:29

      7、   表面電荷:0

      8、   復雜度:226

      9、   同位素原子數量:0

      10、   確定原子立構中心數量:0

      11、   不確定原子立構中心數量:0

      12、   確定化學鍵立構中心數量:0

      13、   不確定化學鍵立構中心數量:0

      14、   共價鍵單元數量:3

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